VaProS, VAriation effect on PROtein Structure and function, is a new data cloud for Structural Life Science and is the core technology to lead the collaboration between the discipline in Structural Biology and the whole Life Sciences. VaProS aims to connect or integrate information in structural biology with genome, transcriptome, interactome and other information, and to provide seamless environment to scientists for analyzing these different types of information derived from different databases. Initially led by the initiative of National Institute of Genetics from 2012 (under the project of Platform for Drug Discovery, Informatics, and Structural Life Science [PDIS]) followed by Waseda Univeristy from 2017 (under the project of Basis for Supporting Innovative Drug Discovery and Life Science Research [BINDS]), VaProS has been developed around the Integrated Structural Biology Databases at Institute for Protein Research in Osaka University, in Tohoku Univeristy, together with the selected outcomes from Protein 3000 Project, Targeted Proteins Research Program, Genome Network Project, and Cell Innovation Project. Newly developed data and databases from the whole organizations of this project, namely Waseda University, Osaka University, Tohoku University, University of Tokyo and Nagahama Institute of Bio-Science and Technology, will be further integrated into VaProS.

The developers of VaProS aim to establish a core technology for drug discovery and other related fields. VaProS provides a bird's eye view of the whole data that assists a hypothesis (model) building process. VaProS also provides information handling environment that enables problem solving toward drug discovery and other related fields. VaProS is going to materialize these aims by connecting and disseminating the outcomes of the national projects in the related fields in the past to both structural biology and the whole life science discipline of not only academia, but industrial sectors as well.

The protein static figures in ribbon model in VaProS-BINDS are provided by Protein Data Bank Japan (PDBj), licensed under CC-BY-4.0 International.

The following description is recommended for the acknowledgement in the work that makes use of this website.

This research is supported by Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from Japan Agency for Medical Research and Development (AMED).

For citation of this website, please refer the following paper.

Gojobori, T., et al (2016) "VaProS: a database-integration approach for protein/genome information retrieval." J. Struct. Funct. Genomics, 17 (4): 69-81.

For keeping a steady flow of maintenance resources for VaProS, let us know how the usage of VaProS benefits you for the research. Please contact us, when the usage of VaProS has led to a scientific publication or a presentation.